First Of Its Kind Study Finds Patients Report Looking An Average Of Five To Six Years Younger Following BOTOX(R) Cosmetic Treatment Facials

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A first-of-its-kind analysis of data
from multiple studies has found that a large proportion of patients report
looking an average of five to six years younger than their current age
after treatment for multiple upper facial lines with BOTOX(R) Cosmetic
(Botulinum Toxin Type A, Allergan, Inc.).(i) As many as 63 percent of
patients receiving BOTOX Cosmetic reported looking younger than their
current age after treatment for upper facial lines -- i.e., moderate to
severe glabellar lines (the vertical "frown" lines between the brows, often
referred to as the "11s"), crow's feet, or multiple facial lines in the
forehead area -- compared to just 23 percent of patients receiving placebo.
The findings were presented today at the American Academy of Dermatology
Academy '06 meeting in San Diego.


"Patient satisfaction is a key measure of success when using BOTOX
Cosmetic to treat facial lines, but clinical trials usually rely on
physician assessments to measure treatment results," said Steven Fagien,
M.D., an aesthetic oculoplastic surgeon in Boca Raton, FL and one of the
study investigators. "The studies included in our analysis are the first to
accurately and reliably assess the patient's own self-perception of age
following BOTOX Cosmetic treatment. Using this approach, we found a
sizeable proportion of patients perceived they looked younger than their
current age following treatment with BOTOX Cosmetic -- an outcome that is
an important goal for many patients seeking medical aesthetic treatments."


For this analysis, data from 249 patients treated with BOTOX Cosmetic
or placebo from five clinical studies were analyzed. Using the
Self-Perception of Age (SPA) measure to directly assess each patient's
perception of his or her own age-related appearance, patients in each of
the clinical studies were asked to indicate whether they feel they look
their current age, younger than their current age, or older than their
current age. The SPA scale was administered both pre-treatment and at four
weeks post-treatment.


At week four post-treatment with BOTOX Cosmetic, 39 percent of patients
receiving 20 U for glabellar lines, 44.8 percent of patients receiving 12 U
for bilateral treatment for crow's feet, and 62.5 percent of patients
receiving 64 U for multiple upper facial lines reported looking an average
of five to six years younger relative to their current age. In comparison,
only 23 percent of patients receiving placebo reported they looked younger
at week four post-treatment.


"Patients treated for multiple facial lines perceived that they looked
younger than those who were treated with BOTOX Cosmetic for glabellar lines
or crow's feet alone. This suggests that the overall, subtle smoothing in
the appearance of facial lines achieved by treating multiple areas may be
an important factor in a patient's perception of looking younger," said
Alastair Carruthers, M.D., a cosmetic dermasurgeon in Vancouver, Canada and
a co-investigator in the study. "In Canada, where BOTOX Cosmetic is
approved for the treatment of multi-facial lines, I have found that by
using the SPA questionnaire with my patients I can work with them to set
appropriate expectations and goals for treatment to ensure optimal
results."


This study was funded by an unrestricted grant from Allergan, Inc.


(i) Carruthers A, Carruthers J, Cox SE, Fagien S, Finn JC, Kowalski JW,
et al. Patients' self-perception of age after botulinum toxin type A
treatment of upper facial rhytids: results across multiple studies.
Presented at the American Academy of Dermatology '06 Meeting (July)
in San Diego, CA. [Poster P2401]


Alastair Carruthers; Steven Fagien

carruthers


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